PI
陈可洋，教授，博士生导师。曾任安徽医科大学公共卫生学院卫生检验与检疫系主任，分子生物学实验室主任，长期从事营养内分泌和临床检验方面教学与科研工作，主要研究方向为2型糖尿病及其并发症,营养内分泌与代谢病。获国家、省自然科学基金多项。自2021年7月任职合肥爱尔眼科医院科教科主任和爱尔眼科医院集团眼科研究所PI。
此外，自复旦大学博士毕业后在美国留学工作多年（2002-2013），科研经历丰富，视野开阔，在HIV-1病毒感染分子机制、吸烟导致肺气肿分子机制、2型糖尿病伴随脂代谢紊乱的分子机制等方面都有建树，先后在Hepatology, JBC, JVI, ATVB, Metabolism-clinical and experimental, Molecular Medicine, European Journal of Nutrition, Translational research, Life Sciences 等国际期刊发表第一或通讯作者SCI论文数十篇。
现为国际动脉粥样硬化学会中国分会理事，中国预防医学会血液安全专委会常委，中国病理生理学会动脉粥样硬化分会专业委员，安徽省营养学会理事。
研究方向：糖尿病视网膜病变发病机制及相关新药研发
主要学术成果
[1] Wang S, Zhou J,
Lu J, Yan Lin , Liu S, Chen K* (陈可洋）. Ketogenic diet improves
vascular hyperpermeability in type 2 diabetic mice
by downregulating vascular pescadillo1 expression. Journal of Cellular and
Molecular Medicine, 2023, 27(10):1410-1422.
IF:5.2, 中科院2区
[2] Zhou J, Lu Y, Lin Y, Li C, Liu J, Jiang Z, Chen
K* (陈可洋）.
Overexpression of hepatic pescadillo-1(PES1) in obesity induces
lipid dysregulation by inhibiting autophagy,
Translational Research, 2023 Feb 10:S1931-5244 (23)00021-x. IF:10.2, 中科院1区
[3] Zhou J, Lu Y, Jia Y, Lu J, Jiang Z, Chen K*（陈可洋）. Ketogenic diet ameliorates lipid
dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1. Mol Med,2022 Jan 3;28(1):1. doi:
10.1186/s10020-021-00429-6. IF: 6.4, 中科院2区
[4] Zhou J, Jiang Z, Lin Y, Li C, Liu J, Tian M,
Liu Y, Chen K*（陈可洋）, The
daily caloric restriction and alternate-day fasting ameliorated lipid
dysregulation in type 2 diabetic mice by downregulating hepatic
pescadillo-1(PES1), European Journal
of Nutrition, 2022, 61(5): 2775-2797. IF: 5.4, 中科院2区
[5] Zhou J, Wang
X, Liu K, Chen K*（陈可洋）.
Association between Helicobacter pylori
infection and the risk of type 2 diabetes mellitus based on a middle-aged and
elderly Chinese population. Endocr J. 2022 Jul
28;69(7):839-846. IF:2.9.
[6] Xing T, Liu Y, Cheng H, Bai M, Chen J, Ji H, He M,Chen K*（陈可洋）. Ligature induced periodontitis in rats
causes gut dysbiosis leading to hepatic injury through SCD1/AMPK signalling
pathway. Life Sci. 2022 Jan 1;288:120162. doi: 10.1016/j.lfs.2021.120162.
IF: 5.8, 中科院2区
[7] Zhou J, Dai Y, Lin Y, Chen K*（陈可洋）. Association between serum amyloid A and
rheumatoid arthritis: A systematic review and meta-analysis. Semin Arthritis
Rheum. 2021 Dec 30:151943. doi:10.1016/j.semarthrit.2021.12.011. IF: 5.5, 中科院2区
[8] Lu Y, Jia Y, Lu J, Liu J, Xu Y, Liu Y, Chen K*（陈可洋）. Progenies of gestational diabetes mellitus
exhibit sex disparity in metabolism after respective therapies of insulin,
glibenclamide, and metformin in dams during pregnancy. Arch Physiol
Biochem. 2021 Oct 23:1-13. doi: 10.1080/13813455.2021.1991957.
[9] Wu X, Chen K (陈可洋), Williams KJ*. An oxide transport chain essential for balanced
insulin action. Atherosclerosis,
2020, 298:42-51.
[10] Zhou J#, Lu Y#, Wang S*, Chen K*（陈可洋）. Association between serum
amyloid
A levels and coronary heart disease: a
systematic review and meta‑analysis of 26 studies. Inflammation Research, 2020 Feb 22. doi:
10.1007/s00011-020-01325-1.
[11] Zhou J #, Dong X #, Liu Y, Jia Y,
Wang Y, Zhou J, Jiang Z*，Chen K*（陈可洋）.
Gestational
hypothyroidism elicits more pronounced lipid dysregulation in mice than
pre-pregnant hypothyroidism. Endocrine Journal, 2020，Mar 10. doi: 10.1507/endocrj.EJ19-0455.
[12] Jiang Z,
Zhou J,
Li T,
Tian M,
Lu J,
Jia Y,
Wan G*, Chen K*（陈可洋）. Hepatic deficiency of Poldip2
in type 2 diabetes dampens lipid and glucose homeostasis. Metabolism-Clinical
and Experimental. 2019,
99: 90-101. IF: 6.54, 中科院2区
[13] Wang Z,
Zhou J,
Lu M,
Liang Y,
Jiang Z*, Chen K*（陈可洋）. Therapy of empagliflozin plus metformin on
T2DM mice shows no higher amelioration for glucose and lipid metabolism than
empagliflozin monotherapy. Life Sci. 2019 Jul 1:116622. doi: 10.1016/j.lfs.2019.116622. IF:
3.4.
[14] Wang J, Jie Sun J, Zhang N, Yang R, Li H,
Zhang Y, Chen K*（陈可洋）, Kong D*.
PES1 enhances proliferation and tumorigenesis in hepatocellular
carcinoma via the PI3K/AKT pathway. Life Sci. 2019, 182-189. IF:
3.4.
[15] Huang L, Yue P, Wu X, Yu T,
Wang Y, Kong D*, Chen K*（陈可洋）. Combined intervention of swimming plus
metformin ameliorates the insulin resistance and impaired lipid metabolism in
murine gestational diabetes mellitus. PLos One, 2018, 13(4):e0195609. doi: 10.1371/journal.pone.0195609. IF: 2.8.
[16] Wang Z, Fan HB, Yang
WW, Mao XD, Xu SH, Ma XP, Wan GP, Yao XM*, Chen K* （陈可洋）. The Correlation
between Plasma Ferritin Level and Gestational Diabetes Mellitus and its Impact on Fetal Macrosomia. J Diabetes Investig,
2018, 9(6),1354-1359. doi: 10.1111/jdi.12836. IF:
4.0.
[17]
Chen K*（陈可洋）, Wu Q, Hu K, Yang
C, Wu X, Cheung P, Williams KJ*.
Suppression of Hepatic Flotillin-1 by Type 2 Diabetes Impairs the Disposal of Remnant
Lipoproteins via Syndecan-1. Arteriosclerosis,
Thrombosis, and Vascular Biology (ATVB), 2018, Jan;38(1):102-113.
IF: 6.9，中科院1区
[18] Cui Y, Liang L, Zhong Q, He Q, Shan X, Chen K（陈可洋）, Huang F.
The association of cancer risks with pentachlorophenol exposure: Focusing
on community population in the areas
along certain section of Yangtze River in China. Environ Pollut. 2017
May; 224:729-738.
[19] Li T#, Chen
K#（陈可洋）, Liu G, Huang LP, Chen L, Wang QW, Hu CL,
Hou LJ. Calorie restriction prevents the development of insulin resistance and
impaired lipid metabolism in gestational diabetes offspring. Pediatr Res. 2017
Apr;81(4):663-671. #: first coauthor. IF: 4.1
[20] Tang W,
Cheng J,
Wang ZY,
Chen KY（陈可洋）, Han ZM,
Wang QH,
Yao YY. The Synergistic Roles of the Chronic Prenatal
and Offspring Stress Exposures in Impairing Offspring Learning and Memory. J
Alzheimers Dis. 2016 Apr
23;53(1):221-36.
[21]
Kraehling JR,
Chidlow JH1,
Rajagopal C,
Sugiyama MG3,
Fowler JW,
Lee MY1,
Zhang X,
Ramírez CM,
Park EJ,
Tao B,
Chen K（陈可洋）, Kuruvilla L,
Larriveé B,
Folta-Stogniew
E, Ola R,
Rotllan N,
Zhou W,
Nagle MW,
Herz J,
Williams KJ,
Eichmann A,
Lee WL,
Fernández-Hernando
C, Sessa WC. Genome-wide RNAi screen reveals ALK1 mediates
LDL uptake and transcytosis in endothelial cells. Nat Commun. 2016
Nov 21;7:13516. doi: 10.1038/ncomms13516. IF: 13, 中科院1区
[22] Chen K（陈可洋）, Williams
KJ*. Molecular mediators for
raft-dependent endocytosis of syndecan-1, a highly conserved multifunctional
receptor. J. Biol. Chem, 2013, 288(20):13988-99. IF: 4.8, 中科院2区
[23] Hassing HC*, Mooij H, Guo S, Monia BP, Chen
K（陈可洋）, Kulik W, Dallinga-Thie GM, Nieuwdorp M, Stroes EG, Williams
KJ. Inhibition of hepatic Sulf2 in
vivo: a novel strategy to correct diabetic dyslipidemia. Hepatology, 2012, 55(6):1746-53. IF: 12.
[24]
Wu X, Chen K（陈可洋）, Williams KJ*. The role of pathway-selective insulin
resistance and responsiveness in diabetic dyslipoproteinemia. Curr. Opin. Lipidol, 2012, 23(4):334-44. IF:
6.1.
[25] Chen
K（陈可洋）, Liu ML,
Schaffer L, Li M, Boden G, Wu X, Williams KJ*.
Type 2 diabetes in mice induces hepatic overexpression of SULF2, a novel
factor that suppresses uptake of remnant lipoproteins. Hepatology,
2010, 52(6):1957-67. IF: 11.8, 中科院1区
[26]
Williams KJ*, Chen K（陈可洋）. Recent insight into factors
affecting remnant lipoproteins uptake. Curr. Opin. Lipidol, 2010, 21(3):218-28.
IF: 6.1
[27]
Huang J, Wang F, Argyris EG, Chen K（陈可洋）, Liang Z, Tian H, Huang W, Squires K,
Verlinghieri G, Zhang H*. Cellular
microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes.
Nature Medicine, 2007, 13(10):1241-1247.
IF: 28, 中科院1区
[28]
Argyris EG, Acheampong E, Wang F, Huang J, Chen K（陈可洋）, Mukhtar M, Zhang H*. The
interferon-induced expression of APOBEC3G in human blood–brain barrier exerts a
potent intrinsic immunity to block HIV-1 entry to central nervous system. Virology, 2007, 367(2):440-51. IF: 3.4.
[29]
Yang B#, Chen K#（陈可洋）, Zhang
C, Zhang H*. Virus-encapsidated
uracil DNA glycosylase UDG and apurinic/apyrimidinic endonucleases APE are
involved in the degradation-dependent antiretroviral activity of APOBEC3G. #: Contribute equally as first authors. J. Biol. Chem, 2007, 282(16): 11667-75. IF: 5.1, 中科院2区
[30] Chen
K（陈可洋）, Huang J,
Zhang C, Huang S, Tong X, Gao L, Nikisher K, Zhang H*. Interferon-α Potently
enhances the Anti-HIV-1 Activity of APOBEC3G in Resting Primary CD4
T-cells. J. Virol, 2006,
80:7645-57. IF: 5.4, 中科院2区
[31] Gao
S, Chen K (陈可洋）, Zhao Y, Rich CB, Li SJ, Toselli P, Stone
P, Li W*. Transcription and posttranscriptional inhibition of Lysyl Oxidase expression by
Cigarette Smoke Condensate in cultured Rat Fetal Lung Fibroblasts. Toxicological. Sciences, 2005, 87(1):
197-03. IF: 4.7.
获得资助的项目：
[1] 国家自然科学基金面上项目 （81570786， 2016/01-2019/12），主持
[2] 安徽省自然科学基金面上项目 （项目号：1508085MH162）， 2015/7-2017/6，主持
[3] 安徽医科大学校科研启动基金 （项目号：0308022101）， 2014-2018，主持
[4] 其他校级和横向基金多项，主持