爱尔眼科实验动物中心

爱尔眼科研究所实验动物中心是研究所核心科研支撑平台之一。中心严格遵循国家《实验动物管理条例》《实验动物质量管理办法》及《实验动物环境及设施》等标准设计建设，集标准化动物饲养、专业化实验操作、精准化功能检测于一体，为眼科临床前研究和基础科研提供全流程、可追溯的技术支撑。

中心受湖南省科学技术厅实验动物管理办公室监管，已取得其颁发的《实验动物使用许可证》（许可证号：SYXK(湘)2023-0004），于 2023 年 6 月正式投入运行。中心动物福利伦理委员会已在湖南省区域科技伦理审查中心完成备案，所有动物实验均经伦理审查批准后实施。爱尔眼科研究所实验动物中心是湖南省实验动物学会理事单位，其规范化运营、高标准管理及突出的科研支撑服务能力多次获得上级单位嘉奖与肯定。

设施涵盖普通清洁级和无特定病原体级（SPF 级）实验动物饲养与实验专区，配套 IVC 独立通气笼具及智能环境调控管理系统，对温度、湿度、压差等关键实验参数实行全自动精准控制、数据自动采集与存储，确保环境条件持续符合国家标准。从硬件与管理层面保障实验结果的一致性、稳定性与可重复性。

中心已搭建全流程实验动物管理系统，覆盖项目管理、实验人员培训、伦理申请、动物采购、饲养、使用、处置等全生命周期，实现实验动物全流程数字化管控与合规溯源，全面契合实验动物管理规范及科技伦理相关要求。

中心设三大功能区域：

A 区 — 屏障环境SPF级动物饲养区：专业承接转基因鼠、免疫缺陷鼠及常规 SPF 级大小鼠的标准化饲养，保障实验动物品质。

B 区 — 普通环境动物实验区：可开展兔、豚鼠等实验动物的相关科学研究。

C 区 — 屏障环境功能检测区：配备国际先进的动物影像、功能及行为学检测设备，涵盖小动物眼电生理诊断系统、眼底成像系统（眼底彩照、FFA、OCT）、全自动大鼠视觉能力测量系统、小动物代谢与行为监测系统、Clocklab 生物节律采集分析系统、新型大小鼠睡眠剥夺仪、以及动物实验跑台、黑白箱、水迷宫等专业设备，支撑高精度眼科相关功能检测与行为学研究。

中心将持续完善质量管理体系，确保实验动物工作合规、安全、高效，为产出高质量、可转化的眼科科研成果提供坚实保障。

Aier Laboratory Animal Resource Center

The Laboratory Animal Resource Center of Aier Eye Institute is one of the core research support platforms. The center has been designed and constructed in strict accordance with national regulations including the “Regulations on the Administration of Laboratory Animals”, “Laboratory Animal – Environment and Facilities” and the “Measures for the Quality Management of Laboratory Animals”.  It integrates standardized animal husbandry, specialized experimental procedures, and precise functional testing, providing end‑to‑end, traceable technical support for ophthalmic preclinical research and basic science.

The center operates under the supervision of the issued by the Laboratory Animal Management Office of the Department of Science and Technology of Hunan Province and holds a "Laboratory Animal Use Permit" (Permit No: SYXK(湘)2023-0004) issued by the office. It officially opened in June 2023. The center’s Animal Welfare and Ethics Committee has been registered with the Hunan Regional Science and Technology Ethics Review Center, and all animal experiments are conducted only after ethical approval. The center is a governing member of the Laboratory Animal Science Society of Hunan, and its operational management, facility maintenance, and research support capabilities have been consistently recognized by the supervisory authorities.

The facility includes dedicated areas for conventional clean-grade (non-SPF) and specific pathogen‑free (SPF) laboratory animal housing and experimentation. It is equipped with an IVC (Individually Ventilated Cage) system and an intelligent environmental control and monitoring system that automated regulates key parameters such as temperature, humidity, and differential pressure, with automatic data acquisition and storage. This ensures that environmental conditions continuously meet national standards. Regular quality control procedures – including environmental testing, microbiological monitoring, and verification of feed and bedding quality – are in place to ensure reliability, stability, and reproducibility of experimental results.

A comprehensive digital management system covers the entire life cycle of laboratory animals, including project management, personnel training, ethics application, animal procurement, housing, use, and disposition. The system ensures full data traceability and regulatory compliance, fully aligning with laboratory animal management standards and ethical requirements.

The center comprises three functional areas:

Zone A – Barrier-Protected SPF Animal Housing Area. Dedicated to standardized housing of transgenic mice, immunodeficient mice, and conventional SPF‑grade rats and mice, ensuring high‑quality experimental animals.

Zone B – Conventional Animal Housing and Experimentation Area. Supports scientific research using rabbits, guinea pigs, and other laboratory animals under conventional housing conditions.

Zone C – Barrier-Protected Functional Testing Area. Equipped with advanced animal imaging, functional and behavioral testing systems, including small animal electrophysiological diagnostics for the eye, fundus imaging systems (fundus photography, FFA, OCT), fully automated rat visual ability measurement system, small animal metabolic and behavioral monitoring system, Clocklab circadian rhythm acquisition and analysis system, novel sleep deprivation apparatus for rats and mice, as well as an animal treadmill, light/dark box, Morris water maze, and other specialized equipment to support high‑precision ophthalmic functional assays and behavioral research.

The center will continue to improve its quality management system to ensure that all laboratory animal activities are conducted in a compliant, safe, and efficient manner, providing a solid foundation for producing high‑quality and translatable ophthalmic research outcomes.

实验动物使用许可证

爱尔眼科实验动物中心任职人员

贺双艳   技术主管

具有湖南省实验动物从业人员合格证书

现任湖南省实验动物学会第一届教育与培训工作委员会委员

现任湖南省实验动物学会第七届理事会理事

现任中国实验动物学会实验动物资源鉴定与评价评审专家

何慧芬  技术主管  兽医

具有湖南省实验动物从业人员合格证书

具有中华人民共和国执业兽医师资格证书

获得荣誉

中心

1、2025年度实验动物工作优秀单位，湖南省实验动物学会

2、2024年度实验动物工作优秀单位，湖南省实验动物学会

个人

1、贺双艳，湖南省实验动物学会2025年度优秀会员

2、贺双艳，湖南省实验动物学会第二届实验动物操作技能大赛-B类操作技能（大鼠尾静脉注射一等奖）

3、贺双艳，第一届中南地区实验动物操作技能大赛-B类操作技能（大鼠尾静脉注射三等奖）

4、彭艳芳，湖南省实验动物学会2024年度优秀会员

如需事务沟通，请联系：

邮件：heshuangyan@aierchina.com