PI
肖佳，中南大学爱尔眼科研究院研究员、博士生导师。主要从事代谢性疾病发病机制与器官对话研究。在Cell Metabolism、Journal of Hepatology、Nature Communications和APSB等国际高水平杂志发表SCI论文60余篇。相关研究获得国家优秀青年科学基金、国家自然科学基金区域联合重点项目、广东省杰出青年科学基金、广东省重大科技专项等国家和省部级课题资助。授权中国专利11项。
主要研究方向：
代表论文：
1. Xiao J#,*, Wang F#, Yuan Yuan#,
Gao JH#, Xiao L, Yan C, Guo FF, Zhong JJ, Che ZD, Li W, Lan T, Tacke
F, Shah VJ, Li C, Wang H*, Dong ED*. (2024) Epidemiology of liver diseases -
Global disease burden and forecasted research trends. Science China-Life
Sciences (Accepted; IF=8.0)
2. Wei XL#, Wu DQ#, Li J#,
Li QH, Che ZD, Cheng X, Wu MM, Yin F, Zhang H, Wang XF, Abtahi S, Zuo L, Hang
L, Ma LL, Kuo WT, Liu XY, Turner JR, Wang H*, Xiao J*, Wang F*. (2024) Myeloid
beta-arrestin 2 depletion attenuates metabolic dysfunction–associated
steatohepatitis via the metabolic reprogramming of macrophages. Cell
Metabolism (Accepted; IF=31.2)
3. Niu YG#, Hu XM#, Song
YL#, Wang CC, Luo PX, Ni SH, Jiao FX, Qiu J, Jiang WH, Yang S, Chen
J, Huang R, Jiang HZ, Chen SH, Zhai QW, Xiao J*, Guo FF*. (2024) Blautia
coccoides is a newly identified bacterium increased by leucine deprivation
and has a novel function in improving metabolic disorders. Advanced Science
e2309255 (IF=15.10)
4.
Zhou ZQ#,
Che ZD#, Mai JC, Zhang R, Luo ZH, Li YF, So KF, Xiao J*, Yao
XS*, Gao H*. (2024) Goji berry-derived phenylpropionyl phenylethylamine
derivatives protect against ethanol-induced hepatic damage. Food Science and
Human Wellness (Accepted; IF=6.99)
5. Che ZD#, Zhou ZY#, Li
SQ, Gao L, Xiao J*, Wong NK*. (2023) ROS/RNS as molecular signatures of
chronic liver diseases. Trends in Molecular Medicine 29(11):951-967
(IF=13.6)
6. Yu Q#, Li C#, Niu QH#,
Wang JG, Che ZD, Lei K, Ren H*, Ma BY, Ren YX, Luo PP, Fan ZM, Zhang H, Liu ZH,
Tipoe GL*, Xiao J*. (2023) Hepatic COX1 loss leads to impaired
autophagic flux and exacerbates nonalcoholic steatohepatitis. Acta Pharmaceutica Sinica B
13(6):2628-2644 (IF=14.90)
7. Che ZD, Song YL, Xu CF, Li W, Dong ZY, Wang
CC, Ren YX, So KF, Tipoe GL, Wang F*, Xiao J*. (2023) Melatonin
alleviates alcoholic liver disease via EGFR-BRG1-TERT axis regulation. Acta Pharmaceutica Sinica B
13(1):100-112 (IF=14.90)
8. Luo PP#, Zheng M#,
Zhang R, Zhang H, Liu YX, Li W, Sun XM, Yu Q, Tipoe GL*, Xiao J*. (2021)
S-allylmercaptocysteine improves alcoholic liver disease partly through
a direct modulation of insulin receptor signaling. Acta Pharmaceutica Sinica B 11(3):668-679 (IF=14.90) (被引13次)
9. Xiao J#, Wang F#, Wong NK., He JH, Zhang
R, Sun RJ, Xu YY, Liu YX, Li W, Koike K, He WL, You H, Miao YL, Liu XW, Meng
MM, Gao B, Wang H*, Li C*. (2019). Global liver disease burdens and research
trends: analysis from a Chinese perspective. Journal of Hepatology 71(1):212-221 (IF=20.58) (被引331次)
代表科研课题：
| 编号 | 所属基金 | 项目名 | 负责人 | 依托单位 | 起始时间 |
| U23A20401 | 区域联合创新基金重点项目 | 酒精肝源AGT引发 “肝-肌对话”造成骨骼肌损伤的关键机制及靶向新药研究 | 肖佳 | 暨南大学 | 2024.01-2027.12 |
| 82122009 | 优秀青年科学基金 | 酒精性肝病发病机制与治疗 | 肖佳 | 暨南大学 | 2022.01-2024.12 |
| 81970515 | 国家自然科学基金面上项目 | 肝细胞NLRP6炎症小体入核过程参与酒精性肝病发病进程的分子机制研究 | 肖佳 | 暨南大学 | 2020.1-2023.12 |