特聘专家

 

王兰，首席科学家(Pre Principal scientist in Simbec and Apitope biotechnology Ltd. UK）

&

 

王兰，首席科学家(Pre Principal scientist in Simbec and Apitope biotechnology Ltd. UK）

1991年获国家公派从西南大学留学英国伦敦大学皇后玛丽学院。

曾担任英国Simbec Reserch公司和Apitope科技公司的首席科学家。

曾任美国Dynex Technologies公司英国分公司高级团队领导，主管研发诊断自身免疫疾病试剂合。在多肽药物研发、临床医学实验等方面有数十年的研究和管理经验。发表30多篇具有学术影响的文章，拥有多项授权中国、美国、英国发明专利，其中专利号为W02010041069A和CN101903777A 项专利已经被商业化。

主要背景

• 生物科学学士学位, 西南大学，生物系 1978-1982

• 细胞生物学硕士学位, 西南大学，生物系（通过研究论文）1982-1985

• 博士学位 (分子生物学) 伦敦大学, 伦敦国王学院1993-1999 

• 助教 (1985-1987), 讲师 (1987-1991) 西南大学，生物系

• 公派访问学者 (教育部）1991至1992 英国伦敦玛丽皇后学院。 获英国文化协会和中国教育部TC项目奖   

• 博士后 英国伯明翰大学生物中心和牙科学院: 组织工程研究, 主要研究如何利用生物可降解支架进行骨再生, 1997-2004

• 研究员 英国剑桥大学生物技术研究所和 Psynova Neurotech Ltd, 负责生物标志物的鉴定, 发表了超过 14 篇论文，成功开发了 3 项专利，涉及多重和胰岛素相关生物标志物，以及精神分裂症的新型治疗策略。2004-2009

• 首席科学家  英国Apitop制药公司, 负责自身免疫性疾病研究, 包括治疗格雷夫斯病和多发性硬化症的新型肽的鉴定和表征研究, 和临床试验 I 和 II 的 开发验证, 完成了多化性硬化病症的一期临床试验，从而顺利二期临床试验。成功筛选出血友病和葡萄膜炎的多肽药物，开发和验证了ATX-GD-59和ATX-F8-1F项目的抗多肽酶免疫检测，从而引领了甲状腺功能失调症和血友病的一期临床试验。2009-2016

• 首席科学家 英国临床研究机构Simbec-Orion , 负责 管理和领导临床项目, 验证 A 型血友病 I 期临床试验的一些特定检测方法,临床医学实验公司。例如：血友病临床一期试验。2017 年1 月-2017 年7月

• 高级团队领导  英国Dynex公司,  负责开发用于诊断一些自身免疫性疾病（如乳糜泻）的自动免疫分析法,  2017-2020

• 高级临床专员/研究员 Worg pharmaceuticals AG , (公司欧洲总部在巴塞尔，瑞士) 负责治疗格雷夫斯病和多发性硬化症的新型肽的临床试验二期FDA和CDE申请 (主要在英国远程工作，也定期去巴塞尔工作). 2021-2023

• 2024年4月迄今, 爱尔眼科医院集团, 担任爱尔眼科研究所特聘专家.

主要研究方向：

1. 临床开发规划的科学策略的制定

2. 治疗性肽和临床研究用于自身免疫性疾病的新肽药物发现/开发

3. 自身免疫性疾病的新型多肽鉴定以及生物标记物鉴定， 研究药物的治疗领域包括：多发性硬化症、格雷夫斯病、A 型血友病和葡萄膜炎

4. 生物标志物识别精神障碍的发现和鉴定

5. 乳糜泻的诊断免疫测定开发、的分子剖析。

 

主要学术成果

 论文

1.  Schwarz E, Whitfield P, Nahnsen S, Wang L, Major H, Leweke FM, Koethe D, Lio P, Bahn S. Alterations of primary fatty acid amides in serum of patients with severe mental illness.  Front Biosci (Elite Ed). 2011 Jan 1; 3:308-14PMID: PubMed 21196311

2.  

3. Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S.Sex-specific serum biomarker patterns in adults with Asperger's syndrome. Mol Psychiatry. 2011 Dec; 16(12):1213-20. PMID: 20877284

4.  

5. Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM, Rothermundt M, Bogerts B, Koethe D, Kranaster L, Ohrmann P, Suslow T, McAllister G, Spain M, Barnes A, van Beveren NJ, Baron-Cohen S, Steiner J, Torrey FE, Yolken RH, Bahn S.  Identification of a biological signature for schizophrenia in serum. Mol Psychiatry. 2011 Apr 12. [Epub ahead of print] [PMID: 21483431]

6.  

7.  Levin Y, Wang L, Schwarz E, Koethe D, Leweke FM, Bahn S. Global proteomic profiling reveals altered proteomic signature in schizophrenia serum. Mol Psychiatry. 2010 Nov; 15 (11):1088-100. Epub 2009 Jun 23. [PubMed PMID: 19546861]

8.  

9. Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S. Sex-specific serum biomarker patterns in adults with Asperger's syndrome. Mol Psychiatry. 2010 Sep 28. [Epub ahead of print] [Pubmed PMID: 20877284]

10.  

11. Cheng TM, Lu YE, Guest PC, Rahmoune H, Harris LW, Wang L, Ma D, Stelzhammer V, Umrania Y, Wayland MT, Li P, Bahn S. Identification of targeted analyte clusters for studies of schizophrenia. Mol Cell Proteomics. 2010 Mar; 9(3):510-22. Epub 2009 Dec 10. [PubMed PMID: 20007949]

12.  

13.  Guest PC, Wang L, Harris LW, Burling K, Levin Y, Ernst A, Wayland MT, Umrania Y, Herberth M, Koethe D, van Beveren JM, Rothermundt M, McAllister G, Leweke FM, Steiner J, Bahn S. Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naive schizophrenia patients. Mol Psychiatry. 2010 Feb; 15(2):118-9. [PubMed PMID: 20098438]

14.  

15. Wang L, Lockstone HE, Guest PC, Levin Y, Palotás A, Pietsch S, Schwarz E, Rahmoune H, Harris LW, Ma D, Bahn S. Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophrenia. J Proteome Res. 2010 Jan;9(1):521-7 [PubMed PMID: 19916557]

16.  

17.  Levin Y, Wang L, Ingudomnukul E, Schwarz E, Baron-Cohen S, Palotás A, Bahn S. Real-time evaluation of experimental variation in large-scale LC-MS/MS-based quantitative proteomics of complex samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 1;877(13):1299-305. Epub 2008 Nov 13 [PubMed PMID: 19056327]

18.  

19. Harris LW, Wayland M, Lan M, Ryan M, Giger T, Lockstone H, Wuethrich I, Mimmack M, Wang L, Kotter M, Craddock R, Bahn S. The cerebral microvasculature in schizophrenia: a laser capture microdissection study. PLoS ONE. 2008; 3 (12):e3964. Epub 2008 Dec 17. [PubMed PMID: 19088852]

20.  

21. Huang JT, Wang L, Prabakaran S, Wengenroth M, Lockstone HE, Koethe D, Gerth CW, Gross S, Schreiber D, Lilley K, Wayland M, Oxley D, Leweke FM, Bahn S. Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues. Mol Psychiatry. 2007 Oct; Epub ahead of print [pubmed PMID: 17938634]

22.  

23. Schwarz E, Levin Y, Wang L, Leweke FM, Bahn S. Peptide correlation: A means to identify high quality quantitative information in large-scale proteomics studies. J Sep Sci. 2007 Aug; Epub ahead of print [pubmed PMID:17683046]

24.  

25. Levin Y, Schwarz E, Wang L, Leweke FM, Bahn S. Label-free LC-MS/MS quantitative proteomics for large-scale biomarker discovery in complex samples. J Sep Sci. 2007 Aug; Epub ahead of print [pubmed PMID:17668910]

26.  

27. Huang JT, Leweke FM, Oxley D, Wang L, Harris N, Koethe D, Gerth CW, Nolden BM, Gross S, Schreiber D, Reed B, Bahn S. Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis. PLoS Med. 2006 Nov;3(11):e428 [pubmed PMID:17090210]

28.  

29. Jake Barralet, Lan Wang, Michelle. Lawson, James Trifitt, Paul. R .Cooper, Dick Shelton Comparison of bone marrow cell growth on 2D and 3D alginate hydrogels. 2005 J Materials Science: Materials in Medicine Vol.16 515-519

30.  

31. Michelle Lawson, Jake Barralet, Lan Wang, Dick Shelton, James T Trifitt  Adhesion and growth of bone marrow stromal cells on alginate hydrogels. 2004 Tissue Eng. 10 (9-10): 1480-91

32.  

33. Lan Wang, Dick Shelton, Paul R Cooper, James T Triffit,  Jake Barralet  Evaluation of Sodium Alginate For Bone Marrow Cell  2003 Biomaterials 24 (20):3475-3481

34.  

35. Wang CX, Wang L, Thomas CR Modelling the mechanical properties of single suspension-cultured tomato cells.  2004 Annal. Bot. 93: 443 – 453.

 

专利
      1. EP2359142 B1/WO2010041069 A1（Biomarkers)
       Publication date Jul 3,2013Inventors: Yishai Levin, Lan Wang, Sabine Bahn
       Applicant: Cambridge Enterprise Limited
      2. EP2708899 A3 (Methods and biomarkers for diagnosing and monitoring psychotic disorders) Inventors: Yishal Levin Sabine Bahn, Lan Wang, Emanue
      Scnsaz George Meallits Publication date: MaV 282014 Applicant: Cambridge Enterornse Limited Effective date: 20150318
      3. Wo 2010041068 A1（Biomarkers) Inventors: Pal Guest, Lan Wang， YsnalL.ewin, Saninn Bann， AonsErnst Publication date: Apr15,2010
      Applicant: Camorndge Ernterarse liomted
      4. US20120040852A1(Biomarkers) Publication date Feb 16,2012
      Inventars.Yiara Lev'n Lan Wang, setrre Bard Orioinal Assignee: Psynova Nerotech Ltd