学术论文_科研成果_最新资讯

2025-09

02

喜报！爱尔眼科研究所获2项重要基金项目

近期，爱尔眼科研究所传来喜讯，两位副研究员在科研项目资助评选中脱颖而出，成功斩获重要课题资助，为眼科领域的研究注入新动力。
2025-05

09

The Gut Microbial System Responds to Retinal Injury and Modulates the Outcomes by Regulating Innate Immune Activation

AbstractPURPOSE. The purpose of this study was to understand how the gut microbi...
2025-05

06

ROS-Responsive Microneedle Patches Enable Peri-Lacrimal Gland Therapeutic Administration for Long-Acting Therapy of Sjögren’s Syndrome-Related Dry Eye

AbstractSjögren's syndrome-related dry eye (SSDE) is a severe dry eye subtyp...
2025-05

06

Senescence Alters Antimicrobial Peptide Expression and Induces Amyloid-β Production in Retinal Pigment Epithelial Cells

AbstractAge-related retinal degeneration, such as diabetic retinopathy and age-r...
2025-05

06

Construction and characteristics of an adjustable biomechanical in vitro corneal stromal model simulating keratoconus pathological features

AbstractKeratoconus (KC) is a prevalent ectatic corneal disease influenced by co...
2025-05

06

The influence of femtosecond laser intrastromal lenticules on the characteristics and maturity in tissue-engineered stem cellderived retinal pigment epithelium sheets

AbstractBackground Recent advances in clinical trials have involved the transpla...
2025-05

03

CRISPR/Cas9-mediated generation of a human induced pluripotent stem cell line with PRPF6 c.2699 G > A mutation to model retinitis pigmentosa

ABSTRACTPRPF6, located on chromosome 20, is required for the formation of the sp...
2025-05

02

Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy

AbstractBackground X-linked juvenile retinoschisis (XLRS) is an inherited disea...
2025-05

02

Risk Factors for Focal Choroidal Excavation Concurrent with Chorioretinal Disease: Evaluated by Spectral-Domain OCT

Purpose: To investigate the risk factors for patients with focal choroidal excav...
2025-05

02

Generation of a gene-corrected isogenic human iPSC line (CSUASOi006-A-1) from a retinitis pigmentosa patient with heterozygous c.5792C > T mutation in the PRPF8 gene

AbstractRetinitis pigmentosa (RP) is a common inherited retinal disease characte...
2025-05

02

Introduction of an RS1 mutation causative variant consistent with identified XLRS patient using CRISPR/Cas9 technology in normal iPSC

AbstractX-linked retinoschisis (XLRS) is a common retinal genetic disease that o...
2025-05

02

Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy

AbstractDiabetic keratopathy (DK), a significant complication of diabetes, often...
2025-05

01

The complement pathway as a therapeutic target for neovascular age-related macular degenerationmediated subretinal fibrosis

AbstractNeovascular age-related macular degeneration (nAMD) is the leading cause...
2024-09

11

Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases

Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal de...
2024-09

05

Development of injectable hyaluronic acid-based hydrogelswith antioxidant activity for the treatment of corneal neovascularization

Corneal neovascularization (CNV) is a condition that can severely adversely affe...
2024-09

04

Diabetes Reshapes the Circadian Transcriptome Profile in Murine Retina

Diabetic retinopathy (DR) is a common complication of diabetes and has a high pr...
2024-09

04

Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids

Diabetic retinopathy (DR) development is associated with disturbances in the gut...
2024-09

04

One-Stop Assembly of Adherent 3D Retinal Organoids from hiPSCs based on 3D-printed derived PDMS Microwell Platform

The three-dimensional (3D) retinal organoids (ROs) derived from human induced pl...
2024-09

04

Microneedles for in situ tissue regeneration

Tissue injury is a common clinical problem, which may cause great burden on pati...
2024-09

04

LM22B-10 promotes corneal nerve regeneration through in vitro 3D co-culture model and in vivo corneal injury model

Corneal nerve wounding often causes abnormalities in the cornea and even blindne...