Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal de...
2024-09-11
- 首页
- 关于我们
概况介绍 研究方向 人才培养 委员会/committee 院士工作站
- 员工团队
特聘专家 主要领导 行政团队 技术团队 PI团队- 科研平台
中心实验室 实验动物中心 生物样本库- 最新资讯
- 首页
- 关于我们
概况介绍 研究方向 人才培养 委员会/committee 院士工作站
- 员工团队
特聘专家 主要领导 行政团队 技术团队 PI团队- 科研平台
中心实验室 实验动物中心 生物样本库- 最新资讯
Establishment of a non-integrate iPS cell line CSUASOi002-A, from urine-derived cells of a female patient with macular corneal dystrophy carrying compound heterozygous CHST6 mutations发布日期： 2024-09-03
Abstract
We report the human induced pluripotent stem cell line (iPSC) CSUASOi002-A, generated from urine-derived cells (UCs) from a 51-year-old female patient carrying compound heterozygous mutations (c.62_63delTinsGA and c.C892T) in the carbohydrate sulfotransferase 6 gene (CHST6). This patient was from a Chinese family of three siblings with macular corneal dystrophy (MCD). Patient UCs were reprogrammed by electroporation using the episomal plasmids (OCT4, SOX2, KLF4, l-MYC, LIN28 and shP53). The human MCD-UiPS cell line CSUASOi002-A retained the disease-associated genotype, while expressed pluripotent stem cell markers and could be differentiated into cells of all three germ layers.
上一篇Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway下一篇The Construction of Retinal Pigment Epithelium Sheets with Enhanced Characteristics and Cilium Assembly Using iPS Conditioned Medium and Small Incision Lenticule Extraction Derived Lenticules相关文章
Corneal neovascularization (CNV) is a condition that can severely adversely affe...2024-09-05
Diabetic retinopathy (DR) is a common complication of diabetes and has a high pr...2024-09-04
Diabetic retinopathy (DR) development is associated with disturbances in the gut...2024-09-04
The three-dimensional (3D) retinal organoids (ROs) derived from human induced pl...2024-09-04
Tissue injury is a common clinical problem, which may cause great burden on pati...2024-09-04
Corneal nerve wounding often causes abnormalities in the cornea and even blindne...2024-09-04
Pre-mRNA processing factors (PRPFs) are vital components of the spliceosome and ...2024-09-04
Propagating large amounts of human corneal stromal cells (hCSCs) in vitro while ...2024-09-04
This study aimed to determine the effect of pinacidil, a nonselective KATP chann...2024-09-04
In vertebrates, most somatosensory pathways begin with the activation of dorsal ...2024-09-04
The pathogenesis of type 2 diabetes mellitus (T2DM) is commonly associated with ...2024-09-04
Corneal fibroblast can be transformed into corneal myofibroblasts by TGF-β1.2024-09-04
Age-related macular degeneration (AMD) is a common vision-threatening disease. T...2024-09-04
Suspended spheroid culture using ultralow attachment plates (ULAPs) is reported ...2024-09-04
Purpose: Retinal inflammation is involved in the pathogenesis of several retinal...2024-09-03
Aging is a risk factor for multiple retinal degeneration diseases. Entraining br...2024-09-03
Angiographically silent cystoid macular edema (CME) is a rare complication from ...2024-09-03
The neuroretina is protected by its own defense system, that is microglia and th...2024-09-03
Purpose: We performed a bioinformatic transcriptome analysis to determine the al...2024-09-03
Previous research has shown that CXCR5−/− mice develop retinal degeneration (RD)...2024-09-03
Purpose: To investigate the levels of matrix metalloproteinases (MMPs) in aqueou...2024-09-03
In vitro generation of a functional retinal pigment epithelium (RPE) monolayer s...2024-09-03
We have established an induced pluripotent stem (iPS) cell line using urine-deri...2024-09-03
Purpose: The purpose of this study is to investigate the potential therapeutic b...2024-09-03
We report the human induced pluripotent stem cell line (iPSC) CSUASOi002-A, gene...2024-09-03
Background Central serous chorioretinopathy (CSC) is a widespread retinal disord...2024-09-03
Glaucoma is characterized by progressive, irreversible damage to the retinal gan...2024-09-03
Subarachnoid space (SAS) around optic nerve can be visible with swept-source opt...2024-09-03
Diabetic eye disease refers to a group of eye complications that occur in diabet...2023-05-01
- 员工团队
- 员工团队